Royal Air Force Typhoon FGR4s have operated alongside France's air force in a coordinated attack targeting an subterranean weapons facility in Syrian territory employed by the IS group, according to the UK Ministry of Defence.
The location, pinpointed through reconnaissance, was thought to be storing arms and explosives, the release indicated, and was positioned in mountains just to the north of the ancient city of Palmyra in the heart of Syria.
"Our aircraft utilized precision-guided Paveway IV munitions to target a several access tunnels down to the depot... preliminary assessments are that the target was engaged successfully," the MoD said.
There was no sign of any civilian impact in the operation conducted Saturday night and every plane involved returned safely, the MoD added.
The Typhoon FGR4s were supported by a Voyager refuelling tanker.
Daesh - alternatively referred to as Daesh - established jihadist rule over significant areas in both Syria and Iraq before its territorial defeat in 2019.
"This operation underscores the UK's leading role, and resolve to stand shoulder to shoulder with our allies, to eliminate any resurgence of the terrorist group and their dangerous and violent ideologies in the Middle East," UK Defence Secretary the minister said.
RAF aircraft have carried out overwatch operations over Syrian airspace to "prevent any attempted resurgence" of the group subsequent to its military defeat at the Baghuz confrontation in the year 2019, the authorities noted.
"I extend gratitude to the personnel of our armed forces who took part in this mission for their expertise and their courage," the Defence Secretary said. "Including them were thousands of UK service members stationed over the festive period. This mission, to remove dangerous terrorists who threaten our way of life, demonstrates how British military are prepared to act, all year round, protecting the UK within its borders and powerful internationally."
In December, the United States armed forces executed what it called a "massive strike" targeting IS targets in the country, after an ambush resulted in the deaths of two American soldiers and a local interpreter in Palmyra.
The UN says Daesh still boasts roughly 5-7 thousand fighters in Syria and Iraq.